Tuber or Not Tuber: The Question of Epileptogenic Lesions in Tuberous Sclerosis Complex (TSC)
نویسندگان
چکیده
منابع مشابه
Tuber or Not Tuber: The Question of Epileptogenic Lesions in Tuberous Sclerosis Complex (TSC).
Commentary In any form of epilepsy associated with distinct anatomical le-sions within the brain, questions arise as to whether the lesional tissue alone is epileptogenic, whether perilesional cortex is also epileptogenic, or whether even more remote cortical regions that appear structurally normal may serve as independent epileptic foci. In disorders associated with multiple distinct lesions, ...
متن کامل"Epilepsy surgery recipes galore": in quest for the epileptogenic tuber in tuberous sclerosis complex.
Tuberous sclerosis complex (TSC) is a genetic disease, the life-long neurological morbidity of which is usually defined early in life, by epilepsy and cognitive delay that typically go hand in hand. Early onset of epilepsy is the one of the important risk factor for continuing seizures and cognitive disability later in life (Curatolo et al. 2008). Early and aggressive treatment of epilepsy is, ...
متن کاملEpileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities
INTRODUCTION Recent evidence has implicated perituberal, MRI-normal brain tissue as a possible source of seizures in tuberous sclerosis complex (TSC). Data on aberrant structural features in this area that may predispose to the initiation or progression of seizures are very limited. We used immunohistochemistry and confocal microscopy to compare epileptogenic, perituberal, MRI-normal tissue wit...
متن کاملTuberous sclerosis: localizing the epileptogenic tuber with synthetic aperture magnetometry with excess kurtosis analysis.
The hallmark of tuberous sclerosis is the presence of multiple cortical tubers. Identifying the epileptogenic tubers is difficult and often requires invasive intracranial electroencephalograph (EEG) monitoring. We report on a patient with tuberous sclerosis upon whom the novel magnetoencephalography (MEG) technique of synthetic aperture magnetometry (SAM) with excess kurtosis (g2) analysis was ...
متن کاملNovel cerebral lesions in the Eker rat model of tuberous sclerosis: cortical tuber and anaplastic ganglioglioma.
The Eker rat is a model for human tuberous sclerosis (TSC) caused by a mutation in the Tsc2 gene. We describe here histological and immunohistochemical findings of the brain lesions in Eker rats, with emphasis on 2 novel lesions found in this study: a cortical tuber and an anaplastic ganglioglioma. The rat cortical tuber resembled those of humans, and further confirmed the value of this animal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2013
ISSN: 1535-7597,1535-7511
DOI: 10.5698/1535-7597-13.5.207